![]() ![]() ![]() Preliminary results on N-acetyl cysteine, Memantine and Topiramate produced significant improvement for pathological gamblers and may open new avenues for treatment. A possible efficacy of opiate antagonist treatment for pathological gambling has been replicated in a number of placebo-controlled studies. In the absence of comorbid psychiatric disorder, these studies did not conclude to the efficacy of these psychotropic drugs. Important studies were carried-out on antidepressants, mood stabilizers, and antipsychotic agents. This paper describes the development of pharmacological treatments for pathological gambling and is based on a review of the literature published in the past 10 years. There are, however, no approved pharmacological treatments for pathological gambling. Title: Psychopharmacological Treatment in Pathological Gambling: A Critical ReviewĪuthor(s): Sophia Achab and Yasser KhazaalĪbstract: Given the rates of pathological gambling and its impact on affected individuals and their relatives, effective treatments are needed. Keywords: Pathological gambling, drugs, antidepressant, lithium, valproate, carbamazepine, naltrexone, nalmefene, topiramate, glutamate, N-acetylcysteine, gambling, antiepileptic, nefazodone, fluvoxamine, paroxetine, sertraline, cyclothymia, olanzapine Still, more well-controlled studies with control of comorbid psychiatric conditions are needed.Given the rates of pathological gambling and its impact on affected individuals and their relatives, effective treatments are needed. Pharmacotherapy may yield beneficial effects in the treatment of pathological gamblers. Mood stabilisers gave improvement in the one placebo-controlled study as well as in both studies with a pre-post design. Opioid antagonists were associated with improvement in one placebo-controlled study and in one study with a pre-post design. ![]() Selective serotonin reuptake inhibitors and similar compounds were associated with improvement in two out of five placebo-controlled studies and in two out of three studies with a pre-post design. Studies for inclusion were identified through searches in PubMed covering the period 1950 to June 2005. Recently, however, several studies investigating the effects of pharmacological interventions have been published. The majority of treatment studies and available treatments today are based upon cognitive-behavioural therapy. The need for effective treatment for pathological gambling is urgent.
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